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References External links Official Site Category:Technical communication toolsSuppressive effect of pulsed ultraviolet radiation on initiation of melanogenesis in B16 melanoma cells. A single s.c. inoculation of B16 melanoma cells in C57BL/6 mice induced melanoma within 7-9 weeks. An application of pulsed ultraviolet (UV) radiation at 1.5 mW cm-2 for 20 min, starting 5 min before tumor cell inoculation and repeated twice a week over 5 weeks, effectively suppressed the tumor induction in the mice. The UV-irradiated mice showed reduced tumor numbers, although tumor induction of the untreated mice also decreased with time. The inhibitory effect on tumor induction was greatest when UV radiation was started 5 min before tumor inoculation and continued for 5 weeks. The inhibition was not observed when UV radiation was started 1-2 h before inoculation, or was followed by a time interval longer than 1 h. The inhibition was inhibited when mice were treated with UV radiation just after tumor inoculation. The treatment also affected the growth rate of established tumors in the animals. The time course of the melanogenesis of the B16 melanoma cells cultured in vitro was similar to that of the tumor development in the animals. When the cells were cultured for 16 days without UV irradiation, melanogenesis was initiated. UV irradiation of the cells completely inhibited melanogenesis as judged by tyrosinase activity and by melanin content. In contrast, melanogenesis was not affected by UV irradiation if the cells were cultured for less than 8 days. These findings indicate that pulsed UV radiation causes a transient suppression of melanogenesis in B16 melanoma cells.The present invention relates to an automatic installation and activation system of the type including a cartridge casing, an electric motor driving a threaded shaft driven by an electric drive motor and an electrical switch controlling the electrical circuit of the electric motor. Such an automatic activation system is used in the field of medicine to control the activation of an implantable stimulator, including electrical, thermal or magnetic stimulators. In the conventional art, such an installation is provided with an installation tool including an electrical connector and a tool connector provided in a flexible cable, each of these connectors having a terminal part for connecting to an electric contact of a stimulator installed in a cartridge casing. This arrangement has the advantage of providing a simple coupling between the installation tool and the stimulator cartridge casing, with a simple connector, and which allows, in particular, the installation of

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